BioT Future Interdisciplinary Technology Mathematics Information Life Sciences

Welcome to BioT Group at Harbin Institute of Technology.

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Research

We focus on developing genomic variant and epigenomic methylation detection algorithms and on uncovering their biological implications using AI technologies.

Large-scale population genomic studies

Develop computational methods to enable cohort-wide analyses spanning individual to population levels.

Cancer Genomic Variant Discovery

Develop algorithms and tools for somatic variant detection and for uncovering biological implications in cancer.

Single-cell multi-omics integration

Integrate scRNA-seq, scATAC-seq, and GWAS data to identify disease-relevant regulatory elements and cell types.

Epigenomic analyses

Integrative Tools for DNA/RNA Methylation Analysis and Population-Level Methylation Mapping.

Pangenome Method Design

Develop algorithms and tools for variant detection and graph-based genome representation at the pangenome level.

Gene fusion analysis

Accurate gene fusion detection in bulk and single-cell data through multimodal biological feature integration.

News


Publications

  • All
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020&before

† first authors with equal contribution, * corresponding authors

[34] Tao Jiang†, Shuqi Cao†, Yadong Liu, Zhendong Zhang, Bo Liu, Ruibang Luo, Guohua Wang*, Yadong Wang*. cuteFC: regenotyping structural variants through an accurate and efficient force-calling method, Genome Biology, 26, 166 (2025). [link, code]

[33] Heng Hu†, Tao Jiang†*, Runtian Gao, Zhongjun Jiang, Shuqi Cao, Yadong Liu, Murong Zhou, Wentao Gao, Shengming Zhou, Guohua Wang*. SVPG: A pangenome-based structural variant detection approach and rapid augmentation of pangenome graphs with new samples, biorxiv. [link, code]

[32] Runtian Gao†, Heng Hu†, Zhongjun Jiang, Shuqi Cao, Guohua Wang, Yuming Zhao, Tao Jiang*. SVHunter Long read based structural variation detection through the transformer model, Briefings in Bioinformatics, Volume 26, Issue 3, May 2025, bbaf203. [link, code]

[31] Wentao Gao†, Sui Wang†, Tao Jiang†, Heng Hu, Runtian Gao, Murong Zhou, Guohua Wang*. Chromosome-scale and haplotype-resolved genome assembly of Populus trichocarpa, Horticulture Research, 2025. [link, code]

[30] Xin Li†, Yadong Liu†, Zhongbo Yang, Yadong Wang* and Tao Jiang*. Comprehensive Benchmarking of Genotype Imputation Tools Using a Large-Scale Chinese Reference Panel, BIBM2024, pp.5218-5223. [link, code]

[29] Zhongbo Yang, Zhenhao Lu, Xin Li, Tao Jiang*, Yadong Wang*, Yadong Liu*. Comprehensive evaluation of haplotype phasing tools with different strategies across diverse sequence technologies, BIBM2024, pp.653-658. [link]

[28] Yadong Liu†, Zhenhao Lu†, Yadong Wang*, Tao Jiang*. GFHunter enables accurate and efficient gene fusion detection in long-read cancer transcriptomes, biorxiv. [link]

[27] Tao Jiang†, Zuji Zhou†, Zhendong Zhang, Shuqi Cao, Yadong Wang*, Yadong Liu*. MEHunter: transformer-based mobile element variant detection from long reads, Bioinformatics, Volume 40, Issue 9, September 2024, btae557. [link, code]

[26] Miao Cui†, Yadong Liu†, Xian Yu, Hongzhe Guo, Tao Jiang, Yadong Wang*, Bo liu*. miniSNV: accurate and fast single nucleotide variant calling from nanopore sequencing data, Briefings in Bioinformatics, Volume 25, Issue 6, November 2024, bbae473. [link, code]

[25] Tao Jiang, Hongzhe Guo, Yadong Liu, Gaoyang Li, Zhe Cui, Xinran Cui, Yue Liu, Yang Li, Anqi Zhang, Shuqi Cao, Tianyi Zhao, Liran Juan, Weize Kong, Ming Chen, Dianming Liu, Hongri Liu, Yixiao Zhang, Kelin Xu, Yongjun Wang, Meian He, Jiancheng Guo, Ming Lu, Jun Chen, Xing Zhao, Genming Zhao, Shaonong Dang, Chao Chen, Xiaojian Wu, Qiyuan Qin, Yixue Li, Hongbing Shen, Li Jin, Bo Liu*, Xingdong Chen*, Yuhong Zhao*, Yadong Wang*. A comprehensive genetic variant reference for the Chinese population. Science Bulletin, 2024. [link]

[24] Heng Hu†, Runtian Gao†, Wentao Gao, Bo Gao, Zhongjun Jiang, Murong Zhou, Guohua Wang*, Tao Jiang*. SVDF: enhancing structural variation detect from long-read sequencing via automatic filtering strategies, Briefings in Bioinformatics, Volume 25, Issue 4, July 2024, bbae336, 2024. [link, code]

[23] Zhendong Zhang†, Yue Liu†, Xin Li, Yadong Liu*, Yadong Wang*, Tao Jiang*. HapKled: a haplotype-aware structural variant calling approach for Oxford Nanopore sequencing data. Frontiers in Genetics, Volume 15, 2024. [link, code]

[22] Yue Liu†, Yuhuan Zhou†, Xiumei Hu†, Wuri Le-Ge†, Haoyan Wang, Tao Jiang, Junyi Li*, Yang Hu*, Yadong Wang*. DIRMC: a database of immunotherapy-related molecular characteristics. Database, Volume 2024, 2024, baae032. [link]

[21] Zhendong Zhang†, Tao Jiang†, Gaoyang Li, Shuqi Cao, Yadong Liu*, Bo Liu*, Yadong Wang*. Kled: an ultra-fast and sensitive structural variant detection tool for long-read sequencing data. Briefings in Bioinformatics, 25 (2), bbae049. [link, code]

[20] Xinran Cui†, Qingyan Lin†, Ming Chen, Yidan Wang, Yiwen Wang, Yadong Wang*, Jiang Tao*, Honglei Yin*, Tianyi Zhao*. Long-read sequencing unveils novel somatic variants and methylation patterns in the genetic information system of early lung cancer. Computers in Biology and Medicine, 171(10299):108174. [link]

[19] Ping Meng, Guohua Wang, Hongzhe Guo*, Tao Jiang*. Identifying cancer driver genes using a two-stage random walk with restart on a gene interaction network. Computers in Biology and Medicine, 158, 106810. [link]

[18] Yadong Liu†, Zhenhao Lu†, Zhongyu Liu, Hongzhe Guo*, Yadong Wang*, Tao Jiang*. Comprehensive evaluation of RNA-seq alignment methods based on long-read sequencing data. BIBM2023. [link, tool]

[17] Tao Jiang, Shiqi Liu, Hongzhe Guo*. Reply: Correspondence on NanoVar's performance outlined by Jiang T. et al. in 'Long-read sequencing settings for efficient structural variation detection based on comprehensive evaluation'. BMC Bioinformatics, 24 (1), 352. [link, code]

[16] Anqi Zhang†, Tangchao Kong†, Baiquan Sun†, Shizheng Qiu†, Jiahe Guo, Shuyong Ruan, Yu Guo, Jirui Guo, Zhishuai Zhang, Yue Liu, Zheng Hu, Tao Jiang, Yadong Liu, Shuqi Cao, Shi Sun, Tingting Wu, Huilong Hong, Bingjun Jiang, Maoxiang Yang, Xiangyu Yao, Yang Hu*, Bo Liu*, Tianfu Han*, Yadong Wang*. A telomere-to-telomere genome assembly of Zhonghuang 13, a widely-grown soybean variety from the original center of Glycine max. The Crop Journal. [link]

[15] Pir Noman Ahmad*, Yuanchao Liu, Khalid Khan, Tao Jiang, Umama Burhan. BIR: Biomedical Information Retrieval System for Cancer Treatment in Electronic Health Record Using Transformers. Sensors, 2023 23(23), 9355. [link]

[14] Tao Jiang, Shiqi Liu, Shuqi Cao, Yadong Wang*. (2022). Structural Variant Detection from Long-Read Sequencing Data with cuteSV. Variant Calling. Methods in Molecular Biology, vol 2493. Humana, New York, NY, 2022. [link]

[13] Yadong Liu†; Zhongyu Liu†; Tao Jiang; Tianyi Zang*; Yadong Wang*. Comparison of the Nanopore and PacBio sequencing technologies for DNA 5-methylcytosine detection. BIBM 2022. [link, code]

[12] Hongzhe Guo†, Zhongbo Yang†, Tao Jiang, Shiqi Liu, Yadong Wang*, Zhe Cui*. Evaluation of classification in single cell atac-seq data with machine learning methods. BMC Bioinformatics, 23 (Suppl 5), 249 (2022). [link, code]

[11] Tao Jiang†, Shiqi Liu†, Shuqi Cao, Yadong Liu, Zhe Cui, Yadong Wang*, Hongzhe Guo*. Long-read sequencing settings for efficient structural variation detection based on comprehensive evaluation. BMC Bioinformatics, 22 (1), 2021, 1-17. [link, code]

[10] Yadong Liu†, Tao Jiang†, Junhao Su, Bo Liu*, Tianyi Zang*, Yadong Wang*. SKSV: ultrafast structural variation detection from circular consensus sequencing reads. Bioinformatics, 2021, btab341. [link, tool]

[9] Gaoyang Li†, Tao Jiang†, Junyi Li, Yadong Wang*. PanSVR: Pan-Genome Augmented Short Read Realignment for Sensitive Detection of Structural Variations. Frontiers in Genetics, 2021, 1486. [link]

[8] Yadong Liu†, Tao Jiang†, Yan Gao, Bo Liu, Tianyi Zang*, Yadong Wang*. Psi-Caller: A Lightweight Short Read-Based Variant Caller With High Speed and Accuracy. Frontiers in Cell and Developmental Biology, 2021, 2139. [link, code]

[7] Zhe Cui†, Ya Cui†, Yan Gao, Tao Jiang, Tianyi Zang* and Yadong Wang*. Enhancement and Imputation of Peak Signal Enables Accurate Cell-Type Classification in scATAC-seq. Frontiers in Genetics, 12, 345, 2021. ISSN=1664-8021. [link]

[6] Tao Jiang†, Yongzhuang Liu†, Yue Jiang, Junyi Li, Yan Gao, Zhe Cui, Yadong Liu, Bo Liu*, Yadong Wang*. Long-read-based human genomic structural variation detection with cuteSV. Genome Biology, 21, 189 (2020). [link, code]

[5] Zhe Cui, Bo Liu, Liran Juan, Tianyi Zang, Tao Jiang, and Yadong Wang*. Assessment of Machine Learning Methods for Classification in Single Cell ATAC-seq. 2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2020, pp. 412-416. [link]

[4] Tao Jiang†, Bo Liu†, Junyi Li, Yadong Wang*. rMETL: sensitive mobile element insertion detection with long read realignment. Bioinformatics, Volume 35, Issue 18, 15 September 2019, Pages 3484-3486. [link, code]

[3] Tao Jiang, Yilei Fu, Bo Liu and Yadong Wang*. Long-Read Based Novel Sequence Insertion Detection With rCANID. in IEEE Transactions on NanoBioscience, vol. 18, no. 3, pp. 343-352, July 2019. [link, tool]

[2] Yilei Fu†, Tao Jiang†, Bo Liu and Yadong Wang*. rCANID: read Clustering and Assembly-based Novel Insertion Detection tool. 2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2018, pp. 219-226. [link, code]

[1] Bo Liu†, Tao Jiang†, S M Yiu, Junyi Li, Yadong Wang*. rMFilter: acceleration of long read-based structure variation calling by chimeric read filtering. Bioinformatics, Volume 33, Issue 17, 01 September 2017, Pages 2750-2752. [link, code]

Members

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Group Leader

Tao Jiang

Faculty of Computing

Professor, Harbin Institute of Technology. (2024.12-)

Associate Prof., Harbin Institute of Technology. (2022.12-2024.12)

Lecturer, Harbin Institute of Technology. (2019.10-2022.12)

PhD., Harbin Institute of Technology. (2015.9-2019.10)

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Ph.D. Student

Yang Li

Faculty of Computing

Ph.D. Student, Harbin Institute of Technology. (2021.3-)

M.Phil., Harbin Institute of Technology. (2018.9-2020.6)

B.Sc., Harbin Engineering University. (2014.9-2018.6)

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Ph.D. Student

Weize Kong

Faculty of Life Sciences and Medicine

Ph.D. Student, Harbin Institute of Technology. (2021.9-)

M.Phil., China Medical University. (2018.9-2021.6)

B.Sc., China Medical University. (2014.9-2018.6)

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Ph.D. Student

Shuqi Cao

Faculty of Computing

Ph.D. Student, Harbin Institute of Technology. (2021.9-)

B.Sc., Harbin Institute of Technology. (2017.9-2021.6)

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Ph.D. Student

Heng Hu

College of Life Sciences

Ph.D. Student, Northeast Forestry University. (2022.9-)

M.Phil., Zhejiang Agricultural and Forestry University. (2019.9-2022.6)

B.Eng., Anhui University of Technology. (2014.9-2018.6)

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Ph.D. Student

Runtian Gao

College of Life Sciences

Ph.D. Student, Northeast Forestry University. (2023.9-)

M.Phil., Henan Polytechnic University. (2020.9-2023.6)

B.Eng., Henan Polytechnic University. (2012.9-2016.6)

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Ph.D. Student

Xin Li

Faculty of Computing

Ph.D. Student, Harbin Institute of Technology. (2025.3-)

M.Phil., Harbin Institute of Technology. (2023.9-)

B.Sc., Northwestern Polytechnical University. (2016.9-2020.6)

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Ph.D. Student

Ziang Meng

Faculty of Computing

Ph.D. Student, Harbin Institute of Technology. (2025.9-)

M.Phil., Case Western Reserve University. (2022.8-2025.5)

B.Sc., Exchange Student, UC Berkeley (Apr. 2021 – Dec. 2021)

B.Sc., Simon Fraser University. (2018.8-2022.5)

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Ph.D. Student

Xin Dai

College of Life Sciences

Ph.D. Student, Northeast Forestry University. (2026.9-)

M.Phil., Harbin Engineering University. (2020.9-2023.6)

B.Sc., Northeast Petroleum University. (2015.9-2019.6)

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M.Phil. Student

Bingyan Wang

Computer Science and Technology

M.Phil. Student, Northeast Forestry University. (2023.9-)

B.Sc., Tongji University. (2019.9-2023.6)

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M.Phil. Student

Hao Zhang

School of Mathematical Sciences

M.Phil. Student, Northeast Forestry University. (2023.9-)

B.Sc., Northeast Forestry University. (2019.9-2023.6)

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M.Phil. Student

Weimin Guo

Faculty of Computing

M.Phil. Student, Harbin Institute of Technology. (2024.9-)

B.Sc., Harbin Institute of Technology. (2020.9-2024.6)

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M.Phil. Student

Xian Chen

Faculty of Computing

M.Phil. Student, Harbin Institute of Technology. (2024.9-)

B.Sc., Henan University. (2020.9-2024.6)

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M.Phil. Student

Changjie Hua

Faculty of Computing

M.Phil. Student, Harbin Institute of Technology. (2024.9-)

B.Sc., Shenyang Ligong University. (2020.9-2024.6)

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M.Phil. Student

Yuansong Zhu

Faculty of Computing

M.Phil. Student, Harbin Institute of Technology. (2024.9-)

B.Sc., Southwestern University of Finance and Economics. (2020.9-2024.6)

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M.Phil. Student

Hongyang Yu

Faculty of Computing

M.Phil. Student, Harbin Institute of Technology. (2025.9-)

B.Sc., Harbin Institute of Technology. (2021.9-2025.6)

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M.Phil. Student

Chuanmin Wu

Faculty of Computing

M.Phil. Student, Harbin Institute of Technology. (2025.9-)

B.Sc., Harbin Institute of Technology. (2021.9-2025.6)

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M.Phil. Student

Yuejin He

Faculty of Computing

M.Phil. Student, Harbin Institute of Technology. (2025.9-)

B.Sc., Harbin Institute of Technology. (2021.9-2025.6)

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M.Phil. Student

Yurui Huang

Faculty of Computing

M.Phil. Student, Harbin Institute of Technology. (2025.9-)

B.Sc., Harbin Institute of Technology, Shenzhen. (2021.9-2025.6)

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M.Phil. Student

Wenjun Pi

Faculty of Computing

M.Phil. Student, Harbin Institute of Technology. (2025.9-)

B.Sc., Central South University. (2017.9-2021.6)

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B.Sc. Student

Tongyu Zhou

School of Architecture and Design

B.Sc. Student, Harbin Institute of Technology. (2021.9-2025.6)

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B.Sc. Student

Yingqi Wang

School of Medicine and Health

B.Sc. Student, Harbin Institute of Technology. (2022.9-)

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B.Sc. Student

Wenbo Zhao

Faculty of Life Sciences and Medicine

B.Sc. Student, Harbin Institute of Technology. (2023.9-)

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B.Sc. Student

Hao Wang

Faculty of Computing

B.Sc. Student, Harbin Institute of Technology. (2023.9-)

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B.Sc. Student

Litian Ouyang

School of Future Technology‌

B.Sc. Student, Harbin Institute of Technology. (2023.9-)

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Alumni

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Ph.D. Student

Zhendong Zhang

2021.9-2024.9

Next position: Postdoctoral fellow in Yale University & Shanghai Jiaotong University

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Ph.D. Student

Yining Xu

2020.9-2023.9

Next position: Selected Graduates in a certain department of China

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M.Phil. Student

Shiqi Liu

2021.9-2023.7

Next position: Selected Graduates in Hangzhou People's Procuratorate

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B.Sc. Student

Junzeng Lv

2021.9-2025.7

Next position: MS in Faculty of Computing, Harbin Institute of Technology (Shenzhen)

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B.Sc. Student

Zuji Zhou

2020.9-2024.7

Next position: MS in School of Computer Science, Delft University

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B.Sc. Student

Tingting Jiang

2022.9-2023.7

Next position: MS in School of Computer Science, The University of Manchester

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B.Sc. Student

Yilei Fu

2018.9-2019.7

Next position: PhD in Department of Computer Science, Rice University

Join us now

We are now looking for self-motivated and optimistic graduate/undergraduate students.
If you are interested in and want to join BioT-Group at HIT, feel free to contact us.

Contact information

Prof. Tao Jiang

tjiang@hit.edu.cn

Room J2011, Technology Innovation Building

Faculty of Computing, Harbin Institute of Technology, Harbin, China